Module membership and gene significance
Web10 aug. 2024 · The first chunk is to calculate Gene Significance GS (the absolute value of the correlation between the gene and the trait) and module membership MM (the … Web29 dec. 2008 · The WGCNA R software package is a comprehensive collection of R functions for performing various aspects of weighted correlation network analysis. The …
Module membership and gene significance
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Web23 jul. 2024 · Module connectivity and is clinical trait relationship identified as the absolute value of the Pearson’s correlation (Module Membership) and gene and the trait (Gene Significance). We set the Module Membership >0.6 and the Gene-Significance >0.3 for candidate hub genes. Moreover, we selected genes in the hub module and applied the … Web6 mrt. 2024 · Finally, we used the overlapping data to identify hub genes. out of a total of 12 identified modules by WGCNA, the blue module was find to have the most statistically significant correlation with prednisolone resistance and Nine genes including SOD1, CD82, FLT3, GART, HPRT1, ITSN1, TIAM1, MRPS6, MYC were recognized as hub genes …
WebContent may be subject to copyright. Module and eigengene network plots. A. Barplot of mean gene significance across modules. In this example we use a trait-based gene significance, Equation 2 ... WebCorrelations between gene module memberships and gene significance for the modules associated with clinical traits. Source publication Gene Co-expression Networks Are …
Web10 apr. 2024 · We constructed a protein-protein interaction network from DEGs followed by network clustering. Members of the two most extensive modules went under the enrichment analysis. We introduced a number of hub genes and gene families playing essential roles in oncogenic pathways and the pathogenesis of gastric cancer. Web10 jun. 2024 · Combining the identified WGCNA modules to meta-modules and subsequent analysis of this meta-modules demonstrated a high correlation with HD (correlation r = 0.5, p-value = 1e-38), a positive correlation between gene significance and module membership of 0.73 (p-value = 2e-54), and the highest mean gene …
WebVisualization of gene significance (GS) vs. module membership (MM) and gene expression levels of significant modules. Scatterplot represents the GS and MM of …
Web Module membership and corresponding gene significance and protein-protein interaction (PPI) network construction of two key modules. (A) Module membership … fitz and floyd nativity sceneWeb1 jan. 2024 · For each expression profile, gene significance (GS) was calculated as the absolute value of the correlation between expression profile and each trait; module membership (MM) was defined as the correlation of expression profile and each module eigengene ( K et al., 2015 ). 2.5. Functional enrichment analysis of co-expression modules fitz and floyd nativityWeb9 feb. 2024 · Module membership (MM) and gene significance (GS) revealed the correlation between the gene expression and infiltrated immune cell abundance. Genes in modules that were highly associated with infiltrated immune cells (correlation ≥ 0.7 and p value ≤ 0.05) were extracted for further study (GS ≥ 0.5 and MM ≥ 0.5). fitz and floyd nevaeh coupeWeb12 aug. 2024 · According to the standard of gene significance (GS) > 0.3 and module membership (MM) > 0.8, I selected 83 hub genes from the key module. As an online … fitz and floyd nativity setWeb17 mrt. 2024 · Gene significance (GS) was used to identify the relationships between genes and traits, and module membership (MM) represented the correlation between MEs and gene expression profiles. Genes having high GS and MM in the key module were highly interrelated with the clinical features. can i have a cold without having a feverWeb27 aug. 2024 · Mechanically, the potential regulators of blue module were investigated. These findings highlight an important role of the blue module and its affiliated genes in … can i have a colonoscopy with hemorrhoidsWebWGCNA gene significance and module membership. I am completing WGCNA on RNAseq data for 3 groups of patients disease responders, non-responders and controls. I am … can i have a concussion without a headache